Spravato: A New Stand-Alone Treatment for Treatment-Resistant Depression

Vinay Saranga • January 28, 2025

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This news was reported by CNBC.com Jan 21, 2025.


For people in Apex, NC, and beyond who have struggled with depression that seems unyielding, there’s exciting news: the FDA has approved Spravato (esketamine) as the first-ever stand-alone therapy for treatment-resistant depression

This groundbreaking treatment offers new hope to those who haven’t found relief through traditional medications.


What Does This Mean for Patients?


Depression affects millions of people in the U.S., with about one-third of those diagnosed experiencing symptoms that don’t respond to standard treatments like oral antidepressants. These symptoms can include persistent sadness, fatigue, sleep disturbances, and even thoughts of self-harm.


Spravato, a nasal spray developed by Johnson & Johnson, has been available since 2019 but was initially approved only in combination with oral antidepressants. Now, patients can use Spravato on its own, offering a fresh alternative for those who have not found success with traditional approaches or who have experienced challenging side effects from oral medications.


How Does Spravato Work?


Spravato is a ketamine-based medication that targets the brain in a unique way. Unlike traditional antidepressants that primarily influence serotonin, Spravato works on a brain chemical called glutamate, which plays a crucial role in mood and cognitive function.


This faster-acting mechanism can provide relief within hours or days, a significant improvement over the weeks or months that traditional medications may take.


Why Is This Approval Important?


  • Freedom and Flexibility: Patients can now choose Spravato as a stand-alone treatment, tailored to their individual needs.
  • Optimized Care: Doctors and patients can personalize treatment plans without relying solely on oral antidepressants.
  • Improved Access: The approval is expected to expand the number of individuals who can benefit from Spravato.


How Is Spravato Administered?


Spravato isn’t a take-home medication. It’s administered in certified outpatient treatment centers like ours in Apex, NC. Patients self-administer the nasal spray under the supervision of trained healthcare professionals and remain in the clinic for observation afterward.


Is Spravato Right for You or Your Loved One?


Spravato is specifically for adults with treatment-resistant depression or those experiencing severe depressive episodes. If you or someone you know has tried at least two antidepressants without success, this innovative treatment could be a promising option.


How We Can Help in Apex, NC


At the North Carolina Institute of Advanced NeuroHealth, we understand how frustrating it can be to face depression that doesn’t seem to lift. Our team is here to guide you through the process of exploring Spravato as a treatment option. We’ll provide:


  • Comprehensive evaluations to determine if Spravato is a good fit.
  • Expert care in a certified treatment center to ensure safe and effective administration.
  • Ongoing support to monitor progress and adjust your care plan as needed.


A Step Toward Hope


Spravato’s FDA approval as a stand-alone therapy marks a significant milestone in depression treatment. If you’re ready to explore new possibilities for managing depression, we’re here to help every step of the way.


Reach out   to our Apex, NC, office today to schedule a consultation and learn more about this life-changing treatment. Together, we can take the next step toward hope, healing, and a brighter future.


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